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Time
SUNDAY (9/30/2018)

Pre-Congress Day

Time
THURSDAY (10/4/2018)

HPP Post-Congress Day
07:30–08:50
Room: Gardenia 2
B/D-HPP EC Meeting
Room: Banda Sea 2
C-HPP EC Meeting
08:15–08:30
Coffee
09:00–09:15
HPP Overview
Gil Omenn. Presentation is available here
(Room: Banda Sea 1)
08:30–9:30
What Exciting Prospects Lie Ahead?
Moderated by Rob Moritz, supported by Jennifer Watson 4-5 min presentations: Jenny van Eyk, Ileana Cristea, Ferdinando Cerciello, Jochen Schwenk, Chris Overall plus five more young investigators being identified: Lightning presentations with general participation.
09:15–10:15
HPP Reports (12 min each)
Chair: Gil Omenn

1. C-HPP (Young-Ki Paik). Presentation is available here.
2. B/D-HPP (Fernando J. Corrales). Presentation is available here.
3. Knowledge Base Pillar (Eric Deutsch & Lydie Lane). Presentation is available here
4. MS Pillar (Sue Weintraub). Presentation is available here.
5. Pathology Pillar (Dan Chan/Ed Nice)
9:30–12:10
HPP Town Hall Meeting
Deep Dive on HPP Goals, Strategy and Deliverables for the next 3 years, and Potential for Big International Translational Projects.
Chairs: Fernando Corrales & Young-Ki Paik

• 09:30-10:10 How can we accelerate identification of the remaining 2186 PE2,3,4 Missing Proteins? Siqi Liu, Eric Deutsch, Lydie Lane, Jochen Schwenk, Nino Bandeira, Chris Overall.
• 10:10-10:50 Identification and functional annotation of PTMs.
Chair: Alexey Nesvizhskii. Ultrafast Methods for Detection of PTMs (Alexey Nesvizhskii)
Results from the 96-phosphopeptide HPP sample community analysis (representative of MS Resource Pillar)
Roles of PTMs in Cardiovascular Disorders (Peggi Angel)
Proteogenomics; splice variants; proteoforms (Neil Kelleher). This presentation is available here.
10:15–12:00
Featured HPP Session
Chair: Mark Baker


1. C-HPP 2.0 Discussion (Chris Overall; 20 min). Presentation is available here.
2. B/D-HPP, Prioritization of Popular Proteins (Kun-Hsing Yu; 20 min)
3. Antibody Validation Initiative (52 min) (Jochen Schwenk, Mathias Uhlen (Peter Nilsson), Cecilia Lindskog Bergström, Heng Zhu, Lydie Lane, Cristina Al-Khalili Szigyarto)
• 10:50-11:30 Functional Studies: Protein-protein interactions; Single-Cell Analyses
How are protein-protein interaction data being incorporated by neXtProt for missing proteins and functionally unannotated proteins? (Lydie Lane)
Methods and applications of single-cell analyses of proteins (Bernd Bodenmiller)
• 11:30-12:10 Translational/Clinical Proteomics Strategies & Priorities
How can we more effectively incorporate proteomics in clinical research across many specialties? (Steve Pennington). This presentation is available here.
What lessons can be learned from international collaborations for Cancer Proteomics and applied for other disease categories? (Henry Rodriguez). This presentation is available here.
12:00–13:00
Lunch and Discussion.
12:10–13:10
Lunch, with HPP Senior Scientific Advisory Board Discussion Outline of Two-Year Strategic Plan for the HPP (Mark Baker). This presentation is available here
Lead Discussants: Cathy Costello, John Yates (Gil Omenn, moderator)
General Discussion
13:00–13:40
Round Table 1
Major Public DBs and MS Data Analysis

(Lydie Lane, Eric Deutsch)

Leaders of neXtProt, PeptideAtlas, and ProteomeXchange will highlight developments at each DB and invite comments and inquiries from end users.
13:00–14:00
Emerging Technologies for the HPP.
(Chairs: Rob Moritz and John Yates).
Using CRISPR/Cas9 genome-editing techniques to modify human iPSC and differentiated cells for Hemophilia B treatment (Bonghee Lee). This presentation is available here.
Proteogenomics: Revisiting human protein-coding genome annotation (Janne Lehtiö. This presentation is available here.
13:40–14:20
Round Table 2
Exploring the Undiscovered “Dark” Proteome

(Young-Ki Paik/Fernando Corrales)

• Accelerating progress to identify and annotate PE2-4 Missing Proteins
• Generating functional annotations for uPE1 Proteins
• Mobilizing/connecting C-HPP and B/D-HPP teams
14:00–15:00
What are the Grand Challenges for the Entire Field of Proteomics
Inspirational speaker: Mike Snyder. Presentation is available here.
General discussion
14:20–15:40
Two Breakout Sessions
B/D-HPP PI Meeting
(Banda Sea 1) and C-HPP PIC Meeting (Banda Sea 2)


B/D-HPP: Open session on Popular Proteins with specific presentations by the PIs of the following initiatives: Rheumatoid Diseases, PediOme, Glycoproteomics, Kidney/Urine-HPP, Diseasome
C-HPP: organizational and scientific strategies (PIs of C-HPP teams)
Part I: Report Session
Part 2: Business Session
Part 3: Election & Free Discussion

Invited Talk: J. Eugene Lee: Ab measurement standardization, KRISS, Korea)
neXt-CP50: Resources
21st C-HPP Workshop in St. Malo
22nd C-HPP Workshop in St. Petersburg
Emerging issues
15:00–15:30
Session devoted to Gil Omenn’s Leadership of the HPP with Light Reception (Chair: Mark Baker).
15:40–17:00
Reception (everyone invited)
HUPO Council Meeting for HUPO Councilors
(Baker, Pennington, Overall, Weintraub, Martens, Hui Zhang, Lane)

Appendix 1

20th C-HPP Workshop, Appendix 1

Sunday HPP Investigators Program

September 30, 2018


The investigators of the HUPO Human Proteome Project will hold their annual workshops to assess and accelerate progress on the major components of the Project: Chromosome-centric HPP teams (C-HPP), Biology and Disease-based HPP teams (B/D-HPP), and the Resource Pillars for Antibody Profiling, Mass Spectrometry, Knowledge bases/Bioinformatics, and Pathology. Specific foci are identification of PE2,3,4 Missing Proteins, generation of functional annotations for uncharacterized uPE1 proteins, and connecting C-HPP and B/D-HPP teams. We aim to complete the “protein parts list” (C-HPP), to stimulate applications of targeted proteomics to organ-specific biological studies (B/D-HPP), and to address many bioinformatics and antibody profiling challenges, as well as the “dark (uncovered) proteome”.
This meeting is open to all Congress registrants; all are welcome.
There is a USD $60 fee to attend the Sunday workshop to defray the catering costs. You can add the workshop ticket via your Congress registration.

07:30-8:50 C-HPP EC (Room: Banda Sea 2) and B/D-HPP EC (Room: Gardenia 2) breakfast working meetings.

Coffee will be available for general participants from 8:40.

9:00-9:15 HPP Overview: Gil Omenn (Room: Banda Sea 1)
 

Presentation in pdf format is available here.

9:15-10:15 HPP Reports (8 min + 4 min Q&A each): Chair: Gil Omenn
  • C-HPP (Young-Ki Paik). Presentation in pdf format is available here.
  • B/D-HPP (Fernando J. Corrales). Presentation is available here
  • Knowledge Base Pillar (Eric Deutsch & Lydie Lane). Presentation is available here
  • MS Pillar (Sue Weintraub). This presentation in pdf format is available here.
  • Pathology Pillar (Dan Chan/Ed Nice)

10:15-12:00 Featured HPP Session: Chair: Mark Baker

  1. C-HPP 2.0 Discussion (Chris Overall; 20 min including questions). Presentation in pdf format is available here.
  2. B/D-HPP, Prioritization of Popular Proteins (Kun-Hsing Yu; 20 min including questions)=-
  3. Antibody Validation Initiative (52 min) (Jochen Schwenk, Introduction, Mathias Uhlen (Peter Nilsson, presentation in pdf format available here), Revised Antibody Validation Pillars; Cecilia Lindskog Bergström (presentation), Validation in HPA/WB and Plasma; Heng Zhu, Antibodies to Transcription Factors; Lydie Lane, Use of Antibody Data in neXtProt; Cristina Al-Khalili Szigyarto, Antibodypedia.

12:00-13:00 Lunch and Informal Discussion

13:00-13:40 Round Table 1: Major Public DBs and MS Data Analysis (Lydie Lane, Eric Deutsch)

Leaders of neXtProt, PeptideAtlas, and ProteomeXchange will highlight developments at each DB and invite comments and inquiries from end users.

13:40-14:20 Round Table 2: Exploring the Undiscovered “Dark” Proteome (Young-Ki Paik/Fernando Corrales)
  • Accelerating progress to identify and annotate PE2-4 Missing Proteins
  • Generating functional annotations for uPE1 Proteins
  • Mobilizing/connecting C-HPP and B/D-HPP teams

14:20-15:40 Two Breakout Sessions: B/D-HPP PI Meeting (Banda Sea 1) and C-HPP PIC Meeting (Banda Sea 2)

B/D-HPP: Open session on Popular Proteins with specific presentations by the PIs of the following initiatives: Rheumatoid Diseases (Francisco Blanco), PediOme (Vera Ignatovich, to be confirmed), Glycoproteomics (Morten Thaysen-Andersen), Kidney/Urine-HPP (Tadashi Yamamoto), Diseasome (Maggie Lam)
C-HPP: organizational and scientific strategies (PIs of C-HPP teams)

15:40-17:00 Reception (everyone invited)

 

15:45 HUPO Council Meeting for HUPO Councilors

Baker, Pennington, Overall, Weintraub, Martens, Hui Zhang, Lydie Lane


II. C-HPP Principal Investigator Council Meeting in Orlando

(Last updated September 14, 2018)
Venue: Banda Sea 2, Loews Royal Pacific Resort, Orlando, FL, USA
Sunday, Sept 30, 2018
14:20-15:40

14:20-14:40 Part I. Report Session:

Chair: Young-Ki Paik
1. Report from Chair: Young-Ki Paik

  • Opening Remarks & Approval of Minutes (2017 PIC meeting)

2. Report from Co-Chairs & Secretary General

  • Status on the JPR SI, 2018 (38 papers) & neXt-MP50 Christopher M. Overall
  • Poster Session Management Lydie Lane & Peter Horvatovich
  • C-HPP Wiki update Peter Horvatovich. This presenttaion in pdf format is here.
  • 19th C-HPP Symposium, Santiago de Compostela Fernando Corrales

14:40-15:20 Part 2 Business Session: •Chair: Christopher M. Overall

The following list of agenda was extracted from the minutes of an C-HPP EC discussion (in EuPA, Santiago, 6/16/2018) and Co-chairs’ conference calls (2018/3-5). Each agenda is given with a brief background for better understanding and clarity.

3. Agenda

Proposition #1: Leadership Rotation (Appendix 1)

Given that the C-HPP’s Phase I is closing this year (2012.9-2018.9), at the Santiago C-HPP workshop, Young-Ki Paik proposed a leadership rotation plan in which Chris Overall (new term: 2019-2021) would be nominated and elected as Chair while Lydie Lane (2018-2020) and Young-Ki Paik (2019-2021) would remain as Co-Chairs.

  • Discussion & Decision:
Proposition #2: Discussion of C-HPP 2.0

At the Dublin-HUPO 2017 Phase II of the C-HPP was approved and will run from 2018.9 to 2021.9. The main scientific missions of C-HPP are focused on identification, annotation, curation and now functional annotation of the human proteome. The focus shifts now to identification of the remaining 10% of the human proteome using a variety of new team approaches with more connection to the pillars and BD. The official uPE1 functionalization project is well and truly up and running and reveals the need to expand collaborations outside HUPO e.g., structural biology, germ cells, biobanks, CRISPR/cas9 etc. Progress will be discussed at the 21st C-HPP Workshop in St. Malo (5/12-14, 2019, Organized by Charles Pineau).
In addition, more aggressive approaches are sought to identify missing proteins using rare tissue samples or rare physiologically conditioned samples.
Taken together, this sets the stage for adoption of new strategies and approaches within the C-HPP to reorientate active teams for Phase II. Discussion of this important strategic plan will continue from the very fruitful discussions at EuPA, Santiago 2018.

  • Discussion:

15:20-15:40 Part 2 Election & Free Discussion
  • Chair: Lydie Lane with assistance of Peter Horvatovich

1. Election of C-HPP EC members

  • Nomination of candidate for EC seat for Asia (1) and America (1)
  • Voting

2. Free Discussion:

  • Special Presentation: Dr. J. Eugene Lee, “Ab measurement standardization”, (Korea Research Institute of Standards and Science, Korea)
  • neXt-CP50: Resources & Technologies:
  • 21st C-HPP Symposium in St. Malo (5/12-14, 2019) Organizer: Charles Pineau, France. Flyer of the Wokrshop in pdf format is available here.
  • 22nd C-HPP Symposium in St. Petersburg (22-26 May or 12-16 June, 2020), Organizer: Alexander Archakov, Russia
  • Emerging Issue: HPP Governance-C-HPP’s position and recommendation
  • AOB


Conclusions: Chair


Click here to go the overview of C-HPP activities in HUPO 2018, Orlando.