Missing proteins
1.1. Chromosome 1
Protein evidence according to NeXtProt for Chromosome 1:
Protein evidence status in text format is available here.
1.2. Chromosome 2
Protein evidence according to NeXtProt for Chromosome 2:
Protein evidence status in text format is available here.
1.3. Chromosome 3
Protein evidence according to NeXtProt for Chromosome 3:
Protein evidence status in text format is available here.
Initial eveidence for proteins with NeXtProt level PE2
Q8N2R8 ProteomeXchange with ID PXD000434 from Lange, Huesgen et al.
1.4. Chromosome 4
Protein evidence according to NeXtProt for Chromosome 4:
Protein evidence status in text format is available here.
1.5. Chromosome 5
Protein evidence according to NeXtProt for Chromosome 5:
Protein evidence status in text format is available here.
1.6. Chromosome 6
Protein evidence according to NeXtProt for Chromosome 6:
Protein evidence status in text format is available here.
1.7. Chromosome 7
Protein evidence according to NeXtProt for Chromosome 7:
Protein evidence status in text format is available here.
1.8. Chromosome 8
Protein evidence according to NeXtProt for Chromosome 8:
Protein evidence status in text format is available here.
1.9. Chromosome 9
Protein evidence according to NeXtProt for Chromosome 9:
Protein evidence status in text format is available here.
Initial eveidence for proteins with NeXtProt level PE2
Q5VXU9 ProteomeXchange with ID PXD000434 from Lange, Huesgen et al.
1.10. Chromosome 10
Protein evidence according to NeXtProt for Chromosome 10:
Protein evidence status in text format is available here.
1.11. Chromosome 11
Protein evidence according to NeXtProt for Chromosome 11:
Protein evidence status in text format is available here.
1.12. Chromosome 12
Protein evidence according to NeXtProt for Chromosome 12:
Protein evidence status in text format is available here.
1.13. Chromosome 13
Protein evidence according to NeXtProt for Chromosome 13:
Protein evidence status in text format is available here.
1.14. Chromosome 14
Protein evidence according to NeXtProt for Chromosome 14:
Protein evidence status in text format is available here.
1.15. Chromosome 15
Protein evidence according to NeXtProt for Chromosome 15:
Protein evidence status in text format is available here.
1.16. Chromosome 16
Protein evidence according to NeXtProt for Chromosome 16:
Protein evidence status in text format is available here.
1.17. Chromosome 17
Protein evidence according to NeXtProt for Chromosome 17:
Protein evidence status in text format is available here.
1.18. Chromosome 18
Protein evidence according to NeXtProt for Chromosome 18:
Protein evidence status in text format is available here.
Number of genes: 275
Number of proteins: 275
Number of validated proteins: 227
Number of proteins awaiting validation: 39
Number of uncertain proteins: 6
| Source | Ensembl prot.-coding genes | neXtProt entries | neXtProt PE1 | PeptideAtlas | GPMdb green | HPA evid. supportive | Our data |
| Baseline* | 276 | 272 | 227 | 195 | 219 | 175 | 275 |
| Missing | 0 | 0 | 50 | 83 | 58 | 102 | 6 |
«In a broad sense, the scope of “missing” master proteins is restricted to unidentified proteins, which detection does not meet the gold threshold of neXtProt, the green threshold of GPMdb, the FDR of 1% at protein level in Peptide Atlas, or confident detection in Human ProteinAtlas».
In our understanding “missing” master proteins don't exist in separate tissue and cells, so these master proteins don't express in human body or cannot be detected due to the limitations of method sensitivity. Zgoda et al., JPR 2013
LIST OF ‘MISSING’ MASTER PROTEINS FOR CHR18 IN RESULTS OF OUR SRM PROTEOME PROFILING
| GENE | AC | Protein name | Our results of transcriptome profiling | ||||
| LIVER | HepG2 cell line | ||||||
| C18ORF64 | J3KSC0 | Putative uncharacterized protein encoded by LINC01387 | Not expression | Not expression | |||
| LDLRAD4 | O15165 | Low-density lipoprotein receptor class A domain-containing protein 4 | Expression | Expression | |||
| PPP4R1 | Q8TF05 | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | Expression | Expression | |||
| ST8SIA5 | O15466 | Alpha-2,8-sialyltransferase 8E | Below thresholds | Below thresholds | |||
| SERPINB10 | P48595 | Serpin B10 | Below thresholds | Not expression | |||
| TTC39C | Q8N584 | Tetratricopeptide repeat protein 39C | Expression | Expression | |||
1.19. Chromosome 19
Protein evidence according to NeXtProt for Chromosome 19:
Protein evidence status in text format is available here.
Initial evidence for proteins with NeXtProt level PE2
Q14773 ProteomeXchange with ID PXD000434 from Lange, Huesgen et al.
1.20. Chromosome 20
Protein evidence according to NeXtProt for Chromosome 20:
Protein evidence status in text format is available here.
1.21. Chromosome 21
Protein evidence according to NeXtProt for Chromosome 21:
Protein evidence status in text format is available here.
Initial eveidence for proteins with NeXtProt level PE2
P57071 ProteomeXchange with ID PXD000434 from Lange, Huesgen et al.
1.22. Chromosome 22
Protein evidence according to NeXtProt for Chromosome 22:
Protein evidence status in text format is available here.
1.23. Chromosome X
Protein evidence according to NeXtProt for Chromosome X:
Protein evidence status in text format is available here.
1.24. Chromosome Y
Protein evidence according to NeXtProt for Chromosome Y:
Protein evidence status in text format is available here.
1.25. Mitochondrial Chromosome
Protein evidence according to NeXtProt for Chromosome Mitochondrial Chromosome:
Protein evidence status in text format is available here.