| SUN, Oct. 5%%%10:00-16:00, Rm D | MON, Oct 6%%%8:00 - 9:20 Room C | TUES, Oct 7%%%8:00 - 9:20 Exhibit Hall | WED, SEPT 8%%%8:00 - 9:20 Room C |
|---|---|---|---|
HPP General Investigators Meeting (Chaired by Gil Omenn) a. Overview of Progress, b. Metrics, and Publications from the HPP c. B/D-HPP Highlights, d. C-HPP Highlights. e. Update of HPP Metrics f. Bioinformatics discussions and standardized re-analyses of major datasets of four major publications in 2014: g. Discussion over working lunch about inter-relationships across HPP components and bioinformatics approaches. h. Antibody and MS Resource Pillars i. SSAB Panel, overview, strategic comments from SSAB members j. Town Hall Meeting Open Forum – on B/D- and C-HPP Collaboration k. Meeting of SSAB with l. HPP-EC for feedback. Details in Appendix 1 |
C-HPP (Part 1) ● New Technology (Chaired by Bill Hancock) a. SRM measurement of missing proteins b. RNA analysis, including predicting when transcript forms protein c. Integration of RNA-Seq and proteomics d. Approaches to ASV and SNV characterization such as down top MS, adoption of protein chemistry methods e. Identification of protein families and sharing of specific data across chromosome families, integrated proteome browser Details in Appendix 2 |
C-HPP (Part 2) ● Poster Session (Chaired by Gyorgy Marko-Varga) Poster Awards (Cash Prize and Award Certificate) will be given to Total 10 Best Outstanding Poster Presenters ● It is required to load the poster no later than 5 pm, Monday. In addition to the C-HPP subjects (e.g., mapping missing proteins, ASV, PTM on each chromosome), any papers related to common technology or resources for C-HPP can also be presented. All eligible presenters should be one of the associated members of C-HPP consortium as of Sept 1, 2014. Further Information in Appendix 3 |
C-HPP (Part 3) ● PIC Meeting (Chaired by Young-Ki Paik) ● Topics: Metrics for success, elections, individual PI updates and Meeting Plans for 2015-2018 Details in Appendix 4 HPP Plenary Session ● 15:00 - 16:50 pm Room A |
Appendix 5
Efforts to Accelerate the HUPO Human Proteome Project
Final Program
To the memory of Juan Pablo Albar
Bus departing Madrid for Segovia will be provided for all participants who register in advance. For details, go to here.
Fernando Corrales, Concha Gil
Young-Ki Paik, Bill Hancock, Jennifer Van Eyk, Tadashi Yamamoto, Pierre Legrain, Gil Omenn
09:10-09:35 A Tissue-Based Map of the Human Proteome: Cross-Validation of HPA antibody data with MS, RNA-Seq and Other Publicly Available Data; Ulrika Qundos, (SciLife Lab, Sweden). Shortened version of this presenation in pdf format is available here.
09:35-09:45 Develop Effective Antibody Capture Reagents for the Missing or Orphan Proteins and for Characterization of Proteoforms of Well-Known Proteins; Collaboration between ProteinAtlas and Monash Monoclonal Ab Facility, Ed Nice (Monash University, Australia). This presentation is available here.
09:45-10:00 Develop and Facilitate Utilization of Common Bio-Banking Samples; Gyorgy Marko-Varga (Lund Univ., Sweden) and Henry Rodriguez (NCI, USA)
10:00-10:10 Analysis of Consecutive Islet Protein Data Sets for Understanding Obesity-Associated Type 2 Diabetes Mellitus; Peter Bergsten for Diabetes-HPP (Uppsala Univ, Sweden)
10:10-10:20 The Proteome-wide SRM Resources: Peptides, Spectral Libraries, PASSEL Database; Robert Moritz and Eric Deutsch (ISB, USA). This presentation is available here.
10:20-10:30 Report on HPP Inter-Laboratory Performance with SRM/MRM Assays; Christoph Borchers (Univ. Victoria, Canada)
10:30-10:40 Extended SWATH Library that makes >10,000 Human Proteins Precisely Measurable; George Rosenberger (ETH Zurich, Switzerland). This presentation in pdf format is available here.
10:40-11:30 Popular Proteins, Quantitative Assays, Functional Networks and Pathways
10:40-10:55 Peipei Ping, CV-HPP, Heart and Vascular Diseases10:55-11:10 Fuchu He, CN-HLPP: Liver Diseases
11:30-11:45 Bridging from the Proteomics Research Community to the Clinic: The ProteomeAnalyzer Project of the B/D-HPP: Robust, Moderate Cost, High Throughput; Bruno Domon (Luxembourg). This presenation is available here.
11:10-11:20 Hui Zhang or Ruth Huttenhain, Cancer-HPP: Cancers
11:20-11:30 Tadashi Yamamoto, HKUPP: Kidney Diseases. This presenation is available in pdf format here.
11:45-12:05 Demonstration of Joint Efforts on MS-based Automated PTM Analysis and Biological Characterization of Brain Proteins and Glioblastoma; Jong Shin Yoo, (KBSI, Korea) and Young-Mok Park (HBPP, Korea). This presentation in pdf format is available here.
12:05-12:20 Demonstration of Utilizing Combined Resources and Technologies from B/D-HPP and C-HPP to Search for Cancer Biomarkers; Gyorgy Marko-Varga of Chr 19 (Lund Univ.), Hui Zhang, Chair, Cancer-HPP (Johns Hopkins, US)
12:20-12:40 Management of RNA Seq Data for Mapping Isoforms (C-HPP) and Characterizing Biological Functions (with B/D-HPP); Ravi Sirdeshmukh (Bangalore, India)
12:40-13:00 Combined Tools for Characterizing Membrane-Embedded Missing Proteins with Disease Implications (AO-HUPO Membrane Proteome Initiative); Takeshi Tomonaga (National Institute of Biomedical Innovation) and Yu-ju Chen of Chr 4 (Taipei, Taiwan). Takeshi Tomonaga presentation's is available here.
14:00-15:00 Panel Discussion: Update on HPP Metrics for High-Confidence Protein Identifications and Missing Proteins combining PeptideAtlas, GPMdb, neXtProt, Human Protein Atlas and including major 2014 datasets
Chair/Moderator: Amos Bairoch (neXtProt, SIB, Switzerland)
Panelists: Lydie Lane (neXtProt, SIB, Switzerland), Eric Deutsch (PeptideAtlas, ISB, USA), Ulrika Qundos (Human Protein Atlas, SciLife Lab, Sweden), Alberto Pascual-Montano (Spain), and Fernando Corrales (Spain), representative of IHPB Working Group
Discussion Topics:
- Reinforcement of Policies on Dataset Deposition with ProteomeXchange, Stringent Protein FDR thresholds, and Reanalysis with Standardized PeptideAtlas and GPMdb Pipelines
- Creation of the Integrated HUPO Human Proteome Browser, or IHPB (Caper, TPB, Genome-wide PDB). Working group for this new project compromised of Ed Nice, Fuchu He, Ping Xu, Ian Smith, Mark Baker, Anthony Beitz, Dong Li, Young-Ki Paik. This presentation is available here.
- Recognition of Reasons Proteins can be Hard to Detect: restricted tissue expression, low abundance, high hydrophobicity or basicity, embedded in membranes, low MW, members of highly homologous protein families
- neXtProt update by Lydie Lane. This presenation is available here.
- Update on neXtProt metrix by Amos Bairoch is available here.
- PeptideAtlas Metrics and Update by Eric Deutsch. This presenation is available here.
- Proteogenomics Dashboard for the Human Proteome Project presented by Alberto Pascual-Montano. This presentation is available here.
- Computational Mass Spectrometry Initiative presented by Shoba Ranganathan. This presentation is available here.
15:00-15:30 Panel Discussion: Focus on PTMs, ASVs, Protein Interactions, protein and glycan chemistry
Chair/Moderator: Cathy Costello (Boston Univ, USA)
Panelists: Bill Hancock (Northeastern Univ, USA), Hisashi Narimatsu (Research Center for Medical Glycoscience at AIST, Japan), Naoyuki Taniguchi (RIKEN Advanced Science Institute, Japan), Gil Omenn (Univ. Michigan, USA)
Presentation of Hisashi Narimatsu on "Glycoproteomics" is available here.
Everyone in the proteomics community is warmly invited to actively participate. We welcome a broad discussion about the development, integration, and wide application of C-HPP, B/D-HPP and Technology Pillars.
- How to make proteomics an essential component of “functional genomics” and integrated ‘omics research?
- How to connect with investigators not part of HPP, including clinical investigators, pathologists, geneticists, biologists?
- How to emphasize characterizing the biology of the many proteoforms of known proteins, while sustaining the effort to complete the parts list?
- How to assist and mobilize less active teams in both B/D-HPP and C-HPP consortium?
- How to accelerate HPP development through coordination between B//D-HPP, C-HPP, and Resource Pillars?
- What should be the focus of the next J Proteome Research C-HPP/HPP Special Issue for mid-2015?
Conclusions and Perspectives
Cathy Costello, Pierre Legrain, Mark Baker, HUPO Presidents Gil Omenn, Chair, HPP Consortium
Presentation of Mark Baker is available here.
Organizers (2014 Post-Congress Workshop in Segovia)
Organizations: PROTEORED and HUPO HPP Consortium
Fernando Corrales, Pamplona, Spain
Concha Gil, Madrid, Spain
Gil Omenn, Chair, HUPO HPP Consortium*
Tadashi Yamamoto, Chair, HUPO Initiative Committee
Young-Ki Paik and Bill Hancock, Chair and co-Chair, C-HPP Consortium
Ruedi Aebersold and Jennifer van Eyk, Co-Chairs, B/D-HPP Consortium
For more information, please contact Lola Segura mdsegura@proteored.org
Interested participants are invited to register here (required). Segovia is located approximately one-hour from Madrid (by train or bus). Transportation TO Segovia on Wednesday evening (October 8) will be provided for all registered participants (by bus). Participants are responsible for their own hotel room Wednesday (Oct 8) and/or Thursday (Oct 9).
- Hotel options in Segovia (participants must book their own hotel)
- Venue Map for Segovia (location of Oct 9 meeting)
- Return transportation options (Segovia to Madrid)
- For additional logisitics information, please contact Lola Segura mdsegura@proteored.org
(* This information is available as wel on http://www.hupo2014.com/newtrends.html.)
Annoncement of Lola Segura regarding Segovia C-HPP Workshop on 7 October 2014
Transportation will be provided (bus) from the Feria de Madrid (Main Conference location) to Segovia (50 min-1h) October 8 evening, as well as coffee and lunch breaks, dinner and a guided City tour (October 9). The remaining expenses of two hotel nights, dinner October 8 and travel back to Madrid by high speed train (35 min, 20 €) should be arranged by each attendee individually. More information about venue and transportation can be found in the website of the workshop: ProteoRed
BUS DEPARTURE: Bus departure is scheduled on 8th October at 20:30h from Hotel Pullman.
However, there will be a Meeting Point at 20:15h at the North Gate of the convention center (Registration Area) to guide the attendees to the buses.
Best regards,
Lola Segura
Transportation Info
- From Madrid: Bus departing Madrid for Segovia will be ready for all participants who signed up for Segovia meeting. More detailed info will be available later.
- From Segovia to Madrid: The participants can select either Bus or Train for returning to Madrid. Unless otherwise, the participants are responsible for their own arrangement of hotel and one way transportation (from Segovia to Madrid). For those invited speakers, there may be separate information as to transportation from/to Madrid/Segovia when the local organizers send them a letter of invitation. This is subject to change.
Click here to go the overview of C-HPP activities in Madrid.