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Time
SUNDAY (9/30/2018)

Pre-Congress Day

Time
THURSDAY (10/4/2018)

HPP Post-Congress Day
07:30–08:50
Room: Gardenia 2
B/D-HPP EC Meeting
Room: Banda Sea 2
C-HPP EC Meeting
08:15–08:30
Coffee
09:00–09:15
HPP Overview
Gil Omenn. Presentation is available here
(Room: Banda Sea 1)
08:30–9:30
What Exciting Prospects Lie Ahead?
Moderated by Rob Moritz, supported by Jennifer Watson 4-5 min presentations: Jenny van Eyk, Ileana Cristea, Ferdinando Cerciello, Jochen Schwenk, Chris Overall plus five more young investigators being identified: Lightning presentations with general participation.
09:15–10:15
HPP Reports (12 min each)
Chair: Gil Omenn

1. C-HPP (Young-Ki Paik). Presentation is available here.
2. B/D-HPP (Fernando J. Corrales). Presentation is available here.
3. Knowledge Base Pillar (Eric Deutsch & Lydie Lane). Presentation is available here
4. MS Pillar (Sue Weintraub). Presentation is available here.
5. Pathology Pillar (Dan Chan/Ed Nice)
9:30–12:10
HPP Town Hall Meeting
Deep Dive on HPP Goals, Strategy and Deliverables for the next 3 years, and Potential for Big International Translational Projects.
Chairs: Fernando Corrales & Young-Ki Paik

• 09:30-10:10 How can we accelerate identification of the remaining 2186 PE2,3,4 Missing Proteins? Siqi Liu, Eric Deutsch, Lydie Lane, Jochen Schwenk, Nino Bandeira, Chris Overall.
• 10:10-10:50 Identification and functional annotation of PTMs.
Chair: Alexey Nesvizhskii. Ultrafast Methods for Detection of PTMs (Alexey Nesvizhskii)
Results from the 96-phosphopeptide HPP sample community analysis (representative of MS Resource Pillar)
Roles of PTMs in Cardiovascular Disorders (Peggi Angel)
Proteogenomics; splice variants; proteoforms (Neil Kelleher). This presentation is available here.
10:15–12:00
Featured HPP Session
Chair: Mark Baker


1. C-HPP 2.0 Discussion (Chris Overall; 20 min). Presentation is available here.
2. B/D-HPP, Prioritization of Popular Proteins (Kun-Hsing Yu; 20 min)
3. Antibody Validation Initiative (52 min) (Jochen Schwenk, Mathias Uhlen (Peter Nilsson), Cecilia Lindskog Bergström, Heng Zhu, Lydie Lane, Cristina Al-Khalili Szigyarto)
• 10:50-11:30 Functional Studies: Protein-protein interactions; Single-Cell Analyses
How are protein-protein interaction data being incorporated by neXtProt for missing proteins and functionally unannotated proteins? (Lydie Lane)
Methods and applications of single-cell analyses of proteins (Bernd Bodenmiller)
• 11:30-12:10 Translational/Clinical Proteomics Strategies & Priorities
How can we more effectively incorporate proteomics in clinical research across many specialties? (Steve Pennington). This presentation is available here.
What lessons can be learned from international collaborations for Cancer Proteomics and applied for other disease categories? (Henry Rodriguez). This presentation is available here.
12:00–13:00
Lunch and Discussion.
12:10–13:10
Lunch, with HPP Senior Scientific Advisory Board Discussion Outline of Two-Year Strategic Plan for the HPP (Mark Baker). This presentation is available here
Lead Discussants: Cathy Costello, John Yates (Gil Omenn, moderator)
General Discussion
13:00–13:40
Round Table 1
Major Public DBs and MS Data Analysis

(Lydie Lane, Eric Deutsch)

Leaders of neXtProt, PeptideAtlas, and ProteomeXchange will highlight developments at each DB and invite comments and inquiries from end users.
13:00–14:00
Emerging Technologies for the HPP.
(Chairs: Rob Moritz and John Yates).
Using CRISPR/Cas9 genome-editing techniques to modify human iPSC and differentiated cells for Hemophilia B treatment (Bonghee Lee). This presentation is available here.
Proteogenomics: Revisiting human protein-coding genome annotation (Janne Lehtiö. This presentation is available here.
13:40–14:20
Round Table 2
Exploring the Undiscovered “Dark” Proteome

(Young-Ki Paik/Fernando Corrales)

• Accelerating progress to identify and annotate PE2-4 Missing Proteins
• Generating functional annotations for uPE1 Proteins
• Mobilizing/connecting C-HPP and B/D-HPP teams
14:00–15:00
What are the Grand Challenges for the Entire Field of Proteomics
Inspirational speaker: Mike Snyder. Presentation is available here.
General discussion
14:20–15:40
Two Breakout Sessions
B/D-HPP PI Meeting
(Banda Sea 1) and C-HPP PIC Meeting (Banda Sea 2)


B/D-HPP: Open session on Popular Proteins with specific presentations by the PIs of the following initiatives: Rheumatoid Diseases, PediOme, Glycoproteomics, Kidney/Urine-HPP, Diseasome
C-HPP: organizational and scientific strategies (PIs of C-HPP teams)
Part I: Report Session
Part 2: Business Session
Part 3: Election & Free Discussion

Invited Talk: J. Eugene Lee: Ab measurement standardization, KRISS, Korea)
neXt-CP50: Resources
21st C-HPP Workshop in St. Malo
22nd C-HPP Workshop in St. Petersburg
Emerging issues
15:00–15:30
Session devoted to Gil Omenn’s Leadership of the HPP with Light Reception (Chair: Mark Baker).
15:40–17:00
Reception (everyone invited)
HUPO Council Meeting for HUPO Councilors
(Baker, Pennington, Overall, Weintraub, Martens, Hui Zhang, Lane)

Appendix 4

20th C-HPP Workshop, Appendix 4

Thursday HPP Day Post-Congress Program

October 4, 2018


The HPP Workshop following the main HUPO2018 Congress program will focus on exciting developments in human proteomics and strategic planning for the HPP. We will draw upon insights from the Congress Program, including the Mon-Wed HPP Track and the Bioinformatics Hub. We will have deep dives into the scientific strategy and goals for the components and collaborations of the HPP. There will be feature presentations and discussions about potential new directions and roadmaps for the next few years. The aim is a two-year strategic plan for HPP, including broad engagement of the biology and clinical communities globally.

All are welcome to this important meeting and to participate in building the future of HPP. There is an HPP-subsidized 100 USD fee to attend the Thursday workshop to defray the catering costs. You can add the workshop ticket through your Congress registration.

08:30–09:30 (Coffee from 8:15)

What Exciting Prospects Lie Ahead? Insights drawn from the Sunday Investigators Meeting, Bioinformatics Hub, the Congress Tracks, and Discussions.
Moderated by Rob Moritz, supported by Jennifer Watson

  • 4-5 min presentations by Jenny van Eyk, Ileana Cristea, Ferdinando Cerciello, Jochen Schwenk, Chris Overall plus five more young investigators being identified
  • Lightning presentations with general participation

09:30–12:10

HPP Town Hall Meeting: Deep Dive on HPP Goals, Strategy and Deliverables for the next 3 years, and Potential for Big International Translational Projects
Chairs: Fernando Corrales & Young-Ki Paik

09:30-10:10

How can we accelerate identification of the remaining 2186 PE2,3,4 Missing Proteins?
Siqi Liu, Eric Deutsch, Lydie Lane, Jochen Schwenk, Nuno Bandeira, Chris Overall

  • Can all proteins be identified at the stringency our Guidelines require?
  • What is the upper limit on detectability of predicted proteins by MS?
  • By MS combined with affinity or physical enrichment methods?

10:10-10:50

Identification and functional annotation of PTMs
Chair: Alexey Nesvizhskii

  • Ultrafast Methods for Detection of PTMs (Alexey Nesvizhskii)
  • Results from the 96-phosphopeptide HPP sample community analysis (representative of MS Resource Pillar)
  • Roles of PTMs in Cardiovascular Disorders (Peggi Angel)
  • Proteogenomics; splice variants; proteoforms (Neil Kelleher). This presentation in pdf format is available here.

10:50-11:30

Functional Studies: Protein-protein interactions; Single-Cell Analyses

  • How are protein-protein interaction data being incorporated by neXtProt for missing proteins and functionally unannotated proteins?? (Lydie Lane)
  • Methods and applications of single-cell analyses of proteins (Bernd Bodenmiller, pending)

1130-1210

Translational/Clinical Proteomics Strategies & Priorities

  • How can we more effectively incorporate proteomics in clinical research across many specialties? (Steve Pennington). This presentation in pdf format is available here.
  • What lessons can be learned from international collaborations for Cancer Proteomics and applied for other disease categories? (Henry Rodriguez). This presentation in pdf format is available here

12:10-13:00

Lunch, with HPP Senior Scientific Advisory Board Discussion

  • Outline of Two-Year Strategic Plan for the HPP (Mark Baker). This presentation is available here
  • Lead Discussants: Cathy Costello, John Yates (Gil Omenn, moderator)
  • General Discussion

13:00-14:00

Emerging Technologies for the HPP
Chairs: Rob Moritz and John Yates

  • Using CRISPR/Cas9 genome-editing techniques to modify human iPSC and differentiated cells for Hemophilia B treatment/potential impact for proteomics, Bonghee Lee, Gachon University School of Medicine, Incheon, Korea. This presentation in pdf format is available here.
  • Proteogenomics: Revisiting human protein-coding genome annotation, Janne Lehtiö, Science for Life Laboratory, Karolinska, Stockholm, Sweden. This presentation in pdf format is available here.

14:00–15:00

What are the Grand Challenges for the Entire Field of Proteomics?
Speaker: Mike Snyder. This presentation in pdf format is available here.

  • General discussion

15:00–15:30

Session devoted to Gil Omenn’s Leadership of the HPP over the past 8 years with Light Reception
Chair: Mark Baker

Click here to go to the overview of C-HPP activities in HUPO 2018, Orlando.