SUNDAY (9/17/2017)

O’Brien Center for Sciences, Univ. College Dublin

THURSDAY (9/21/2017)

HPP Post-Congress Day
O’Brien Center for Sciences, Univ. College Dublin
George Moore Auditorium
B/D-HPP EC Meeting
Room 2%%%C-HPP EC Meeting
George Moore Auditorium
Highlights from the Sunday Investigators meetings and the Congress
• Moderated by Mike Snyder

Topics discussed:
Wellness, Single Cell, DIA, Clinical Assays, Small volume, Speed BM Matthias Mann 1M ions and Need to get more qunatitative
Coffee & Tea
Status of the Missing Proteins neXt50 Challenge

Overall and all Chr teams, after teams’ report on Sunday. JPR special issue update.
Greetings / Introduction
HPP Overview

Gil Omenn

This presentation is available here.
Coffee Break
C-HPP session

Young-Ki Paik, Lydie Lane and Chris Overall
TAMPA Action Plans (neXt50, Bioinformatics, MP Functional Study)

Presentation of Young-Ki Paik is available here.
Presentatation of Christopher Overall is available here.
Organ-specific Popular Proteins (and Popular PTM-Proteins)

Liver (F. Corrales), CVD (J. van Eyk)
Kidney (T. Yamamoto)
• Data mining to prioritize disease related proteins (M Snyder).
Presentation available here.
B/D-HPP session

Jennifer van Eyk/Fernando J. Corrales
Coffee & Tea available in hall, no break time allocated

Presentation of Paolo Roncana is available here.
Lunch and informal discussion with SSAB

• N. Taniguchi, M. Snyder
Pillars session 1. Knowledge base

Lydie Lane.
This presentation is available here.
A Deep Dive on PTMs
Pillars session 2. Capture reagents-HPA

Jochen Schwenk
New Classes of PTMs:Functional Characterization, and Databases

• S. Weintraub, Intro
• Y. Zhao (crotonylation and related)
• J. Fert-Bober (citrullination)
• H. Yu (succinylation)
• P. Xu (ubiquitination)
Pillars session 3. Mass spectrometry

Sue Weintraub
This presenatation is available here
Nicki Packer
This presentation is available here.
New MS Approaches for Detection of PTMs

• R. Moritz. This presentation is available here.
Boxed Lunch: Take lunch and return
Panel on Future Directions

• Y.-K. Paik, P. Yang.
Presentation of Young-Ki Paik is available here and
of Pengyuan Yang is available here.
SSAB Panel for Progress and Future Directions for SSAB (members to be invited) Q&A

Cathy Costello, Leroy Hood, Michael Snyder, Mathias Uhlén
Timetable for Deliverables

• Status of JPR 2017 Special Issue 2017 high-impact articles: online as accepted, release in Dec 2017%%%• Other significant publications
• 2018 baseline metrics: PeptideAtlas 2018-01, neXtProt 2018-02
B/D HPP workshop

13:30–14:00 Popular Proteins
14:00–14:15 Eyeome - Richard Semba
14:15–14:30 Mitochondria - M. Fasano
14:30–14:45 Muscle skeletal-L.Ferrucci
14:45–15:00 Brain - Katrin Marcus
15:00–15:15 Extreme condition - E. Nikolaev
15:15–15:45 Cancer - Connie Jimenez
15:45–16:00 Rheumatoid disease - F. Blanco
C-HPP workshop
(Appendix 1)

I. 13:30-14:15 PIC Meeting
II.14:15-15:00 Cross Chromosome Strategy
III.15:00-15:50 New Plans
• Chr 3: Takeshi Kawamura
• Chr 6: Christoph Borchers. Presentation available here.
• Chr 19: Sergio Encarnación-Guevara
• Chr 21: Albert Sickmann
• Chr X: Yasushi Ishihama. Presentation available here
Evidence of Translation Products from IncRNAs or smORFs

• T. Wang: Potential lncRNA Translation Products
• Gong Zhang (Jinan Univ., China)
on Translatome-guided de novo Identification of Proteins
• Discussion: E. Deutsch and L. Lane.
Presentation of Eric Deutsch is available here.
Plenary Session

New Technology & Resource Sharing B/D and C-HPP
Light Reception and Conclusion
Shuttle transfer to CCD for Opening Plenary and Welcome Reception*

*Shuttle times arranged at 15:00 for those going to CCD for Council Meeting and 17:00 for Opening Ceremony

Appendix 1

C-HPP Principal Investigator Council Meeting in Dublin

(Last updated August 13, 2017)
Sunday, Sept 17, 2017

Chair: Young-Ki Paik, Co-Chairs: Lydie Lane and Chris Overall

Session I. PIC Meeting Agenda (13:30-14:15)

13:30-13:50 Part I. Report Session: Quorum Report

Chair: Young-Ki Paik

  1. Report from Chair: Young-Ki Paik
Opening Remarks & Approval of Minutes (2016 PIC meeting)
Annual C-HPP Report to HUPO Council (see Appendix 2)
Other Ongoing C-HPP Efforts. This presentation is available here.
  1. Report from Co-Chairs & Secretary General
Status on the JPR SI, 2017 & next-50 Christopher M. Overall
neXtProt and Poster Session Management Lydie Lane & Peter Horvatovich
C-HPP Wiki update Peter Horvatovich (presentation available here).
Others From PIC members
13:50-14:15 Part 2 Business Session

Chair: Christopher M. Overall

  1. Extension of C-HPP Working Terms
    (Current: 2012/2022 (10 yrs.) Revised: 2012/2027 (15 yrs.)).
    Rationale: Considering the current speed of progress in detection and characterization of missing proteins (MPs), it may be necessary to proposed to extend the current terms to 2027, giving more time to carry on functional studies of MPs along with newly identified proteoforms.

  2. Election of Co-Chair: As one of Co-chairs’ term (Lydie Lane) is to end by 12/31, 2017, we need discuss on this matter. If the current co-chair wants to stand for another term, we will do vote for formal approval.
  3. Setting up MOU between Chr teams to boost cluster activity (e.g., Chr Y and KC-HPP)
  4. Confirmation of Future C-HPP Workshop/Symposium Plans: 2016-2020 (by Organizers)
  • 19th C-HPP Workshop in Santiago, Spain (w/EuPA Congress) June 16/17 2018 (F. Corrales)
  • 20th C-HPP Workshop in Orlando, FL, during 17th HUPO Congress 9/30-10/3, USA, 2018
  • 21st C-HPP Workshop in St. Malo, France, May13-14, 2019 (C. Pineau)
  • 22nd C-HPP Workshop in Moscow, Russia. TBA, 2020 (A. Archakov)

Note: As discussed in Tehran workshop, we will establish a separate session for Young-Investigator from Santiago Workshop in 2018 (details on this program will be available later).

Session II. Cross Chromosome Strategies (14:15-15:00)

Chair: Young-Ki Paik, Chris Overall and Lydie Lane

Proposals and Discussion (Potential Topics)

  1. Method Development: C-HPP SRM Cluster (Alexander Archakov)-8 min-10 min
    Q. How best can we improve methodological approaches to find low abundance MPs? Combines genetics and proteomics to study complexes in whole chromosomes
  2. Rare Tissues and Cell Lines Cluster (Chris Overall)-8 min-10 min
    Q. How can obtain rarely used biological samples for discovery and characterization of MPs? How best we can use cell lines and interactome info for functional study of MPs?
  3. MissingProteinPedia Case study (Mark Baker)-8 min-10 min
  4. Integrated Data Formats (Lydie Lane and Eric Deutsch)-10 min
    Q: What would be most challenging problems in integrating whole human proteome? How best we can integrate those datasets from characterizing MPs such as alternative splice variants (ASVs), lncRNA, RNC RNAs into the current proteome DB? How can we combine the genomic resources (e.g., ENCODE, H-DBAS, DB-AT etc.) with proteome DB to create an integrative human omics DB? The smORF proteins (or mini-proteins).
  5. Novel Protein Study Cluster (Charles Pineau) 8-10 min
    Q. Where can we start from?
  6. Any Suggestions?

Session III. Introduction of New C-HPP Teams (15:00-15:50)

Chair: Lydie Lane
Chr 3 Takeshi Kawamura (JAPAN)
Chr 6 Christoph Borchers (CANADA)
Chr19 Sergio Encarnacion-Guevara (MEXICO). This presentation is available here.
Chr 21 Albert Sickmann (GERMANY)
Chr X Yasushi Ishihama (JAPAN). This presentation is available here.

16:00-16:50 Break for Plenary Session

Click here to go the overview of C-HPP activities in HUPO 2017, Dublin.