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27th (C-)HPP Workshop and 20th HUPO Congress program

C-HPP Workshop on Next Steps for the C-HPP and neXtProt

29 May 2023 7:34 PM

The C-HPP is holding a workshop prior to the HUPO 2023 Congress in Busan, Korea at the Centum Premier Hotel in the "Chelsea and Liverpool rooms" on Sunday, 17th September, 09:30 –15:00.

After the workshop, the HUPO Council Meeting (by invitation at 15:30), Opening Plenary (17:45) and Welcome Networking Reception (19:30) will take place at the BEXCO Convention Center, just one block away. The Sunday workshop allows for attendees to arrive on Saturday, facilitating transfers from ICN if not arriving in Busan, and for the international attendees to rest and recover before the main conference.

Those who would like to be present are asked to register using the this spreadsheet

Agenda

The main foci for the Workshop are (i) short business meeting for reports and C-HPP Chromosome team updates and elections. Then we move to the second focus of this workshop which would be new directions for the C-HPP with a Human Proteome PTM action plan, MPs, and CP50 (as part of the Grand Challenge) and neXtProt.

Preliminary Program

09:30 Meet and Greet coffee/tea

10:00-12:00 Session 1

Welcome, quick Chromosome Team updates:

  • neXtProt, human proteome numbers from the 2023-04-18 release (Lydie Lane, Eric Deutsch, Nuno Banderia),
  • HPP (Cecilia Lindskog)
  • JPR Special Issue (Chris Overall)
  • Other business from matters arising from the PIC.
  • Special presentation on “Chemoproteomics as an enabling technology for the aims of the C-HPP for PTM, MPs or CP50 research” by Ho Jeong Kwon, Director, Chemical Genomics Leader Research Initiative, Yonsei University, President-Elect, Korean Society for Biochemistry and Molecular Biology (KSBMB).


12:00 - 13:00 Lunch

13:00 Session 2: Future Aims and plans for the C-HPP/HPP and neXtProt

Discussions will include new directions for the C-HPP with an action plan for Human Proteome PTM, MPs, and CP50 (as part of the Grand Challenge) incorporating neXtProt.

15:00 Meeting closes

(15:30 HUPO Council)


HPP Day (September 21, 2023) – Emerging Strategies to Address Protein Functions 


The Human Proteome Project (HPP) is HUPO’s flagship project. It is designed to map the entire human proteome in a systematic effort using currently available and emerging techniques. In 2021, the HPP launched the Grand Challenge, the objective of which is to identify a function for every human protein. During the HPP Day at HUPO 2023, different strategies to predict or address the functional properties of proteins in the context of cells will be presented and discussed. Be sure to register for this outstanding program! All HUPO 2023 delegates are welcome to attend.

08:00 – 10:30 Session 1: Mission and Current Status

  • 08:00 Welcome and Introduction – Charles Pineau, France & Cecilia Lindskog, Sweden
  • 08:05 Overview of the Grand Challenge and Reflections from 2022 – Charles Pineau, France. This presentation in pdf format is available here.
  • 08:15 2nd Update on the π-Hub Project – Fuchu He, China
  • 08:45 2nd Update on the Chinese Westlake Pilot Project – Tiannan Guo, China. This presentation in pdf format is available here.
  • 09:00 The HPP-ChemBioFrance Pilot Project – Charles Pineau, France. This presentation in pdf format is available here.
  • 09:15 Proteins in Time and Space – Spatial Proteomics for Predicting Function – Cecilia Lindskog, Sweden
  • 09:30 Exploring the unseen human proteome – Gong Zhang, China (cancelled)
  • 09:45 Involving Undergraduates in the HPP Grand Challenge: The Functionathon Experience at the University of Geneva – Lydie Lane, Switzerland


10:30 - 10:45 Coffee Break

10:45 – 12:30 Session 2: How Should We Get Organized to Contribute to the Grand Challenge?

  • 10:45 Current HPP Structure and Suggestions of Future Directions – Charles Pineau, France
  • 11:00 4x Breakout Sessions
  • 11:30 Summaries from the Different Sessions and General Discussion


12:00 - 13:00 Lunch Break

13:00 – 15:30 Session 3: Moving Forward – Strategies and Initiatives to Predict Protein Function(s)

  • 13:00 How to Propose Protein Function Based on Cellular Localization – Kathryn Lilley, UK (cancelled)
  • 13:30 Proteomics and Protein Function in Clinical Precision Medicine and Pathology – Michael Roehrl, USA
  • 14:00 Location matters! Position-specific Glycosylation Impacts Protein Function - Morten Thaysen-Andersen, Australia
  • 14:30 Discussion on Future Directions - All
  • 15:25 Wrap Up – Charles Pineau, France


Important note


During the discussion of "13:00 Session 2: Future Aims and plans for the C-HPP/HPP and neXtProt" Charles Pineau provided a proposition for to describe the functional annotation status of human proteins as follows:

Molecular Function vs. cellular/network function

  • FE1: (Gold) Direct function shown with orthogonal confirmation (another substrate, same substrate, different lab, biochemical, MS, antibody, e.g. to Phosphosite

? Candidate FE1 has one set of data but no orthogonal confirmation

  • FE2: (Silver) Direct or indirect association with function. e.g., knockdown or overexpression led to a phenotype by association. i.e., protein is involved in a pathway, but not known its specific function.

Orthologue function in other species with known function.

  • FE3: (Bronze) Function inferred by homology with other family members but not directly or indirectly associated with the function.
  • FE4: Predicted function by AI/ML/ other
  • FE5: protein with unknown function known, by direct or indirect association, homology or function.
  • uPE1: unknown function of a PE1 protein (tools available for its study)
  • Proteins with unidentified functions = FE2 – FE5.